Search results for "evolution [galaxies]"
showing 10 items of 84 documents
Cancer stem cell definitions and terminology:the devil is in the details
2012
The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key t…
Evolutionary convergence and nitrogen metabolism in Blattabacterium strain Bge, primary endosymbiont of the cockroach Blattella germanica.
2009
Bacterial endosymbionts of insects play a central role in upgrading the diet of their hosts. In certain cases, such as aphids and tsetse flies, endosymbionts complement the metabolic capacity of hosts living on nutrient-deficient diets, while the bacteria harbored by omnivorous carpenter ants are involved in nitrogen recycling. In this study, we describe the genome sequence and inferred metabolism of Blattabacterium strain Bge, the primary Flavobacteria endosymbiont of the omnivorous German cockroach Blattella germanica. Through comparative genomics with other insect endosymbionts and free-living Flavobacteria we reveal that Blattabacterium strain Bge shares the same distribution of functio…
The Fitness Effects of Random Mutations in Single-Stranded DNA and RNA Bacteriophages
2009
Mutational fitness effects can be measured with relatively high accuracy in viruses due to their small genome size, which facilitates full-length sequencing and genetic manipulation. Previous work has shown that animal and plant RNA viruses are very sensitive to mutation. Here, we characterize mutational fitness effects in single-stranded (ss) DNA and ssRNA bacterial viruses. First, we performed a mutation-accumulation experiment in which we subjected three ssDNA (ΦX174, G4, F1) and three ssRNA phages (Qβ, MS2, and SP) to plaque-to-plaque transfers and chemical mutagenesis. Genome sequencing and growth assays indicated that the average fitness effect of the accumulated mutations was similar…
On Approximation of Entropy Solutions for One System of Nonlinear Hyperbolic Conservation Laws with Impulse Source Terms
2010
We study one class of nonlinear fluid dynamic models with impulse source terms. The model consists of a system of two hyperbolic conservation laws: a nonlinear conservation law for the goods density and a linear evolution equation for the processing rate. We consider the case when influx-rates in the second equation take the form of impulse functions. Using the vanishing viscosity method and the so-called principle of fictitious controls, we show that entropy solutions to the original Cauchy problem can be approximated by optimal solutions of special optimization problems.
Doubly nonlinear equations with unbounded operators
2004
Abstract The solvability of the evolution system v′(t)+ B (t)u(t)∋ f (t),v(t)∈ A (t)u(t) , 0 A (t) are bounded, possibly degenerate, subdifferentials and B (t) are unbounded subdifferentials.
Nonexistence of solutions to higher order evolution inequalities with nonlocal source term on Riemannian manifolds
2022
We establish sufficient conditions for the nonexistence of nontrivial solutions to higher order evolution inequalities, with respect to the time variable. We consider a nonlocal source term, and work on complete noncompact Riemannian manifolds. The obtained conditions depend on the parameters of the problem and the geometry of the manifold. Our main result recovers some nonexistence theorems from the literature, established in the whole Euclidean space.
An abstract doubly nonlinear equation with a measure as initial value
2007
Abstract The solvability of the abstract implicit nonlinear nonautonomous differential equation ( A ( t ) u ( t ) ) ′ + B ( t ) u ( t ) + C ( t ) u ( t ) ∋ f ( t ) will be investigated in the case of a measure as an initial value. It will be shown that this problem has a solution if the inner product of A ( t ) x and B ( t ) x + C ( t ) x is bounded below.
The Dirichlet problem for the total variation flow
2001
Suppose that Ω is an open bounded domain with a Lipschitz boundary. The purpose of this chapter is to study the Dirichlet problem $$ \left\{ \begin{gathered} \frac{{\partial u}} {{\partial t}} = div\left( {\frac{{Du}} {{\left| {Du} \right|}}} \right)in Q = \left( {0,\infty } \right) \times \Omega , \hfill \\ u\left( {t,x} \right) = \phi \left( x \right)on S = \left( {0,\infty } \right) \times \partial \Omega , \hfill \\ u\left( {0,x} \right) = u_0 \left( x \right)in x \in \Omega \hfill \\ \end{gathered} \right. $$ (5.1) where u0 ∈ L1(Ω) and ϕ ∈ L1 (∂Ω). This evolution equation is related to the gradient descent method used to solve the problem $$ \begin{gathered} Minimize \int {_\Omega \lef…
Intensīvu profesionālu angļu valodas mācību kursu izveide “Evolution Latvia” darbiniekiem
2018
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Molecular mechanisms involved in the regulation of stress response in Oenococcus oeni and experimental evolution
2020
Oenococcus oeni is the main bacterium responsible of malolactic fermentation in wine. This lactic acid bacteria grow in the stressful wine environment (high ethanol content, sulfites, low pH and low temperatures….). To maintain its cellular homeostasis, O. oeni has established mechanisms of resistance to its ecological niche. This research work focuses on the adaptative response of O. oeni to its environment and especially to acidity. Two approaches have been implemented (1) First, a targeted approach to characterize the molecular actors involved in regulating the general stress response. The RNA interference technique made possible the characterization of the repressor CtsR as well as two …